INDOLE-2-CARBOXYLIC ACID

Synonyms. Indole-2-carboxylic acid; 2-Carboxyindole; 1H-Indole-2-carboxylic acid; 2-Indolecarboxylic acid; 1H-Indol-2-carbons; 1H-Indole-2-carboxylate; 2-Indolecarboxylate; Indole-2-carboxylate; 1H-Indole-2-carbonsäure; ICA;

INDOLE-2-CARBOXYLIC ACID

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PRODUCT IDENTIFICATION

CAS RN

1477-50-5

EINECS RN

216-030-4

FORMULA

 C9H7NO2

MOLE WEIGHT

161.16

H.S CODE

 2933.99.7900

SMILES

 C1=CC=C2C(=C1)C=C(N2)C(=O)O

CLASSIFICATION

 

EXTRA NOTES

 

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

off-white to yellowish crystalline powder

MELTING POINT

205 ~ 209 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY

 

VAPOR DENSITY

 

log P(octanol-water)

 1.95

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 0, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Indole-2-carboxylic acid

Google Scholar Search - Indole-2-carboxylic acid

U.S. National Library of Medicine - Indole-2-carboxylic acid

PubChem Compound Summary - Indole-2-carboxylic acid

NCBI (http://www.ncbi.nlm.nih.gov/) -  Indole-2-carboxylic acid

http://www.sigmaaldrich.com/
Application
·Reactant for total synthesis of (±)-dibromophakellin and analogs
·Reactant for synthesis of the pyrrolizidine alkaloid (±)-trachelanthamidine
·Reactant for stereoselective preparation of renieramycin G analogs
·Reactant for preparation of spirooxoindolepyrrolidines via reduction of indole-2-carboxylic acid followed by oxidation, condensation, reduction, amidation and Kharasch radical cyclization
·Reactant for Pd-catalyzed cyclization
·Reactant for preparation of N,N'-(pentane)diylbis[indolecarboxamide] and N,N'-[phenylenebis(methylene)]bis[indolecarboxamide] derivatives6

 

SALES SPECIFICATION

APPEARANCE

off-white to yellowish crystalline powder

ASSAY

99.0% min

MELTING POINT

205 ~ 209 C

WATER

0.5% max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD CLASS

 

PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Not a dangerous substance. Potential Health Effects: Eyes - May cause eye irritation. Skin - May be harmful if absorbed through skin May cause skin irritation. Inhalation - May be harmful if inhaled. May cause respiratory tract irritation. Ingestion - May be harmful if swallowed.

HAZARD CODES

 

RISK PHRASES

 

SAFETY PHRASES

 

 

PACKING

Preserved in light-resistant and well-closed bottles

 

PRICE INFORMATION